New footjoy weste herren daily persistent headache is a continuous, unremitting headache, notorious for its unresponsiveness to aggressive medical interventions.The underlying pathophysiology of new daily persistent headache is poorly understood resulting in unending, chronic pain.However, a prior study identified elevated tumor necrosis factor alpha within the cerebral spinal fluid of new daily persistent headache patients.
Herein, seal cookie cutter we report on a patient who suffered with headache for 6 years failing to respond to over 20 different medical treatments, but found drastic improvement and eventual resolution with Venlafaxine.This drug binds to the 5-HT 2A receptor inhibiting tumor necrosis factor alpha signaling.Therefore, we hypothesize a chronic inflammatory mechanism driving new daily persistent headache pathology.